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Abstract

Research Article

Pharmacological Manipulation of the Aging Pathways to Effect Health Span and Lifespan with Special Reference to SGLT2 Inhibitors as Powerful Anti-aging Agents in Humans

David K Murdock*

Published: 30 October, 2024 | Volume 8 - Issue 1 | Pages: 011-025

Calorie restriction has been shown to slow the aging process in numerous organisms including primates. Caloric excess states, such as type 2 diabetes, are associated with accelerated aging and the incidence and severity of chronic diseases. The nutrient-sensing pathways and intestinal microbiome are important systems that affect aging and chronic disease development. This manuscript reviews the various pathways involved with aging and chronic disease development and examines the pharmacological manipulation of these systems which appear to slow aging and the chronic diseases of aging in experimental model organisms and collaborating human data when available. Finally, the abundance of experimental and human data suggesting the newer diabetic medications, the sodium-glucose transport inhibitors, are potent anti-aging agents is provided.

Read Full Article HTML DOI: 10.29328/journal.ibm.1001028 Cite this Article Read Full Article PDF

Keywords:

Aging; Chronic diseases of aging; SGLT2 inhibitors

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University of Agriculture, Pakistan

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Assaf Harofeh Medical Center, Israel

Leonid Feldman

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University of Port Harcourt Teaching Hospital, Nigeria

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Ekiti State University, Nigeria

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Helen Figge

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Ph.D, Boston University Department of Communication Sciences and Disorders and Knowledge Research Institute, Inc., 2131 Reflection Bay Drive, Arlington, Texas 76013, USA

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Department of Neurosurgery, Queen Elizabeth Hospital, Hong Kong

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Palestine College of Nursing, Khan Younis, Gaza Strip, Palestine

Ayman M Abu Mustafa

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Department of Agricultural Economics, Agribusiness and Extension, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

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