Published: 30 October, 2024 | Volume 8 - Issue 1 | Pages: 011-025
Figure 1:
Summarizes many of the biological effects occurring during calorie restriction. The down regulation of mTOR due to falling insulin and IGF levels as well as the inhibitory effects of AMP kinase activation leads to a switch from anabolic to catabolic processes. Sirtuin activation occurs and the net effect is a marked decrease in oxidative damage, inflammation, proteotoxins, and activation of the cellular clean-up mechanisms including genomic repair, apoptosis, and autophagy. These cellular repair and preservation measures are felt to be instrumental in the slowing of aging and the occurrence of chronic disease processes observed with CR. See text for details. AA: amino acids, IGFs: insulin-like growth factors, NF-kB: nuclear factor kappa B.
Read Full Article HTML DOI: 10.29328/journal.ibm.1001028 Cite this Article Read Full Article PDF
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